Senior Scientist

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

The Position

We advance science so that we all have more time with the people we love.

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

The Opportunity

We are seeking a highly skilled and motivated Senior Scientist leading a Research Group exploring lysosomal and/or mitochondrial biology, specifically in the context of neurodegenerative diseases. The successful candidate will play a key role in our R&D team, driving the discovery and development of novel therapeutic strategies. The lab will be embedded in the Neurotechnologies Section within the Neuroscience and Rare Disease (NRD) therapeutic area. The primary focus of the section is on implementing innovative disease-modifying techniques and models to tackle therapeutic targets of unmet clinical need.

We are offering an outstanding opportunity to lead a lab whose primary focus will be drug discovery in neurodegenerative diseases. A particular therapeutic focus will be the application of your in-depth knowledge of lysosomal and mitochondrial biology.

You will be leading a R&D working group in an exciting and fast-progressing therapeutic area. You will develop new therapy strategies and manage research programs in neurodegenerative and neuromuscular disorders. You will be responsible for applying scientific expertise and judgement to initiate, design, direct and execute experiments and/or studies in support of research and/or development project goals in a time sensitive manner. You will have tremendous resources and capabilities, and you will be surrounded by world-class scientists and drug hunters in a state-of-the-art new building located at the pRED center in Basel.

Your key responsibilities

• You are leading an effective team of Scientists and Associates to explore and target lysosomal and/or mitochondrial pathways to suggest new therapeutic avenues

• You are leading drug discovery projects, ensure successful translation of pre-clinical programs to a clinical setting and design innovative research projects focused on the role of lysosomes and mitochondria in neurodegenerative and neuromuscular diseases.

• You implement research models with endpoints that support understanding of patient disease and biomarkers.

• You collaborate with cross-functional teams, including our Biomarker teams, Therapeutic Modalities and Pharmaceutical Sciences groups and Data & Analytics to convert hypotheses into innovative therapeutics.

• You analyze, interpret and present complex data to internal and external stakeholders

• You act as an impactful contributor and/or leader of project teams and seminal initiatives. You foster creativity, productivity, execution with a sense of urgency, teamwork, accountability, cross functional collaboration, and employee growth and development.

Who you are

• You completed a PhD or MD/PhD in Cell Biology, Molecular Biology, Neuroscience, or a related field, with a focus on lysosomal and/or mitochondrial biology.

• You bring a minimum of 5 years solid research experience (after your PhD) in lysosomal and/or mitochondrial biology. Experience in neurodegenerative disease research is highly desirable.

• You bring a proven scientific-track record through impactful publications, or substantial contributions to drug development programs. Experience in drug development is a clear asset for the role.

• You are a rigorous scientist with a strong expertise in cellular and molecular techniques, including electrophysiological, high-content imaging, cell-based and biochemical assays, multiplexed protein assays, polymerase chain reaction, RNAi, RNASeq and flow cytometry methods.

• You are someone who is driven by the desire to find therapeutics for some of the most devastating disorders.

• You have experience in preparing high quality documents including technical reports, presentations, SOPs and experimental protocols. Experience in regulatory filings is a plus.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more .

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.