Genetics & Genomics Lab research associate (m/f/d)

For one of our clients, and international pharma company in Basel, we are looking for a Genetics & Genomics Lab research associate.

In this role you will play a key role in the development and implementation of genomic assays for biomarker analysis in both pre-clinical and clinical settings. Your primary responsibility will be hands-on laboratory work, driving innovation and advancing our understanding of genetic and genomic mechanisms in support of therapeutic development.


General Information:
 

• Start date: ASAP
• Latest start date: February 2025
• Planned duration: 2 years
• Extension: possible
• Workplace: Basel
• Workload: 100%
• Remote/Home Office: occasionally possible
• Travel: no
• Team: 25
• Working hours: Standard

Tasks & Responsibilities:
 

• Develop, validate, and implement genetics and genomics-based biomarker assays (e.g., epigenetics, SNVs, CNVs, gene expression signatures, circulating DNA/RNA) to support pre-clinical studies and early-phase clinical trials, characterizing pharmacodynamics and mechanisms of action for novel therapeutics.
• Evaluate and apply cutting-edge genetics and genomics technologies (e.g., single-cell sequencing, spatial-omics, ddPCR) to maximize insights from limited and valuable pre-clinical and clinical samples following GCP standards
• Deliver high-quality biomarker data to project biology and biomarker teams, ensuring impactful contributions to therapeutic development.
• Ensure compliance with Safety, Health, and Environment (SHE) regulations in all laboratory and operational activities, contributing to a safe and sustainable research environment.
• Inspire and train other scientists and associates in applying novel technologies and facilitate the transfer of innovative methods to external collaboration partners.

Must Haves:
 

• Master's degree or higher in molecular biology, biochemistry, or a related field with substantial experience in biomarker assay development in pre-clinical or clinical settings.
• Deep hands-on expertise in molecular biology techniques (e.g., qPCR, ddPCR) and next-generation sequencing (NGS) platforms, including single-cell and spatial-omics technologies.
• Proficiency in developing, validating, and applying genomic assays across multiple platforms and sample types (e.g., tissue, liquid biopsies).
• Familiarity with implementing genetics and genomics assays in compliance with Good Clinical Practices (GCP) is a plus.
• Fluency in English is required, German would be nice to have
• Ability to think creatively and rigorously in evaluating and developing new technologies for current and emerging scientific modalities.
• Strong focus on ensuring operational compliance in the storage e.g. tracking, and management of samples and data, adhering to established regulatory and organizational standards.
• Strong team player with a collaborative spirit, able to work independently and within agile, matrixed teams.

Nice to Have:
 

• Previous Pharma experience