Post-doctoral position to study zygotic genome activation and lineage specification in zebrafish

Introduction

UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV and Epalinges. As an employer, UNIL encourages excellence, individual recognition and responsibility.

Presentation

Prof. Nadine Vastenhouw (https://www.vastenhouwlab.org) at the Center for Integrative Genomics at UNIL is seeking a postdoc with a background in any of the life sciences, interested in nuclear organization and transcription regulation.

Job information

Expected start date in position: 01.09.2024 / to be agreed

Contract length: 1 year, renewable, max 5 years

Activity rate: 100%

Workplace: University of Lausanne, Dorigny campus

Your responsibilities

The regulation of transcription during vertebrate embryogenesis is one of the most poorly understood - and yet critically essential - developmental processes. The goal of our research is to study how the transcriptional machinery and chromatin template are brought together in time and space to robustly regulate transcription during development.

 

After fertilization, animals go through cleavage divisions that transform the one-cell egg into a multicellular embryo. During this phase, the genome is inactive, and embryos rely on the products their mothers provided them. During the maternal to zygotic transition, developmental control is handed from maternally provided gene products to those synthesized from the zygotic genome. The onset of transcription is an excellent system to determine how all of the different variables that influence the decision to transcribe a gene or not come together to generate complex transcriptional programs.

 

We use zebrafish embryos as they allow us to combine molecular biology & biochemistry, genetics & genomics, and imaging & biophysics to study transcription regulation in the context of early embryonic development.

 

Most of your time will be dedicated to research, but you will also have the opportunity to be involved in teaching activities (e.g. practical class preparation, literature reading classes, Master project supervision).

Your qualifications

- A PhD degree in any of the life sciences

- Interest in transcription regulation, nuclear organization, and quantitative biology

- Excellent scientific writing, communication, and interpersonal skills

What the position offers you

You will be supervised by Prof. Nadine Vastenhouw, in a diverse, dynamic, and international research laboratory. The working language is English.

 

The Center for Integrative Genomics encompasses 15 research labs investigating diverse fields related to functional genomics and offers state-of-the-art experimental facilities. Beyond the training in the host laboratory, numerous possibilities exist at UNIL for further professional education and career development.

Contact for further information

Informal requests for further information can be made by email to:

E-Mail schreiben

Your application

To apply, you must upload as a single PDF document:

• A CV, including the names of 3 referees


• A motivation letter in English describing your past research experience and your scientific interests, and how they are a good match for the host laboratory.

 

Deadline: July 12, 2024

 

Only applications (word or PDF) through the University of Lausanne job portal will be taken into account.

We thank you for your understanding.

Additional information

UNIL is committed to equal opportunities and diversity.
www.unil.ch/egalite

UNIL supports early career researchers.
www.unil.ch/graduatecampus