PhD Position - Development of in situ Bioprinting Technologies

100%, Zurich, fixed-term

Articular cartilage injuries are widespread and can increase the risk of early onset osteoarthritis. The fields of tissue engineering and bioprinting are constantly searching for new methods to create biomimetic tissue models which better replicate the organization of native tissues. Here bioprinting strategies have the potential to revolutionize the functionality of tissues used in regenerative medicine.

The Tissue Engineering and Biofabrication Laboratory (Prof. Marcy Zenobi-Wong) within the Department of Health Sciences & Technolgy (D-HEST) at ETH Zürich in Zurich, Switzerland, uses bioprinting to produce tissues which address unmet clinical needs. The laboratory has recently developed a light-based 3D printing technique, capable of creating topological cell guiding cues in large scaffolds ( centimeter scale) based on optical modulation instability effect and self-focusing effect on non-linear media (e.g., photosensitive resin). This allows for creating efficient cell guiding microstructures including microfilaments and microchannels in 3D hydrogel constructs within seconds. In this multi-PI consortium, an in situ printing technique will be developed to treat articular cartilage injuries.

Project background

The goal of this project is to develop a light based printer which can be used directly in the operation room. This new printer will be able to crosslink photoresins and cells directly into the patient’s cartilage defect, thereby promoting regeneration of the joint.

Job description

• Design, assembly and validation of in situ bioprinting system
• Assessment of print fidelity
• Establish and test software-hardware control of the system
• Optimization of safety, reliability and accuracy of the printer
• Integration of multiple printheads to increase functionality of printer
• Training and maintence of printer for consortium partners

Profile

You have a diploma/M.Sc. degree in mechanical engineering or biomedical engineering with strong motivation to develop the hardware and software behind the next generation of 3D bioprinters. The following skills are sought:

• 3D printing: Familiarity with light based and extrusion 3D printers, as well as characterization of 3D printing materials
• Physics and Optics: Understanding of optics, lasers, diffraction, fiberoptics
• Hardware Design and Mechatronics: Understanding of communication between devices and communication protocols
• Programming: Proficiency in python and understanding of basic software engineering
• Good knowledge of Linux operating system, especially in combination with Raspberry Pi operation and Arduino
• Motivation to work in a multidisciplinary and multicultural environment
• This project is embedded within a large European consortium, therefore excellent written and oral communciation are essential

Workplace

We offer

• An open and collaborative research environment
• Access to and training in cutting-edge methodologies and instrumentation
• Possibilities to develop entrepreneural skills and training

We value diversity

Curious? So are we.

We look forward to receiving your online application with the following documents:

• A motivation letter describing how your background fits the profile, your scientific interests and scientific achievements to date (max. 2 pages)
• CV and Transcripts from MSc and BS degrees
• Contact information of 3 references

The position is available from January 1, 2025.

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

Further information about our laboratory can be found on our website . Questions regarding the position should be directed to Prof. Marcy Zenobi-Wong, Tel 044 632 5089 or email marcy.zenobi@ hest.ethz.ch (no applications).

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.