PhD Position in Chemical Biology

100%, Zurich, fixed-term

The research group for Chemical Biology and Molecular Imaging ( Frei Research Group ) at ETH Zurich is looking for a doctoral researcher to develop chemistry inspired tools for advanced fluorescence microscopy and then use the tools to study dynamic cellular processes. The position is fully funded.

Research in the Frei Research Group focuses on the development of novel chemigenetic tools such as fluorescent biosensors and perturbation tools. We implement these technologies with cutting edge fluorescence microscopy techniques including super-resolution microscopy and fluorescence lifetime imaging to investigate cell signaling and metabolism.

Job description

The position focuses on the development of chemigenetic tools that combine synthetic fluorophores with genetically encodable components like self-labeling protein tags for application in cell biology. The work is highly interdisciplinary and collaborative, involving synthetic chemistry and/or protein engineering as well as cell biology and fluorescence microscopy. The position is available from Fall 2025 onwards or earlier upon agreement.

Profile

We are looking for someone with:

• A MSc degree in Chemistry, Chemical Biology, Biochemistry or a closely related discipline
• Strong communication skills and proficiency of the English language
• Strong motivation and curiosity for research in Chemical Biology
• Motivation to work in a multidisciplinary and multicultural environment
• Prior experience in at least one of the following: synthetic chemistry, fluorophore chemistry, molecular biology, protein engineering, cell biology or fluorescence microscopy.

Workplace

We offer

ETH Zurich is a family-friendly employer with excellent working conditions and offers highly competitive salaries .

Moreover, our research group offers:

• An open and collaborative research environment
• Access to and training in cutting-edge methodologies and instrumentation (e.g. ScopeM)
• Career development under direct mentorship

Working, teaching and research at ETH Zurich

We value diversity

Curious? So are we.

We look forward to receiving your online application with the following documents:

• Curriculum Vitae including the name and contact information of at least two referees
• A cover letter detailing your research background and research interests ( 1 page)
• Academic transcripts (Bachelor and Master)

Please note that we exclusively accept complete applications submitted through our online application portal. Applications via email or postal services will not be considered.

Applications will be considered on a rolling basis and the application portal closed by 2nd of Mai 2025.

Questions regarding the position should be directed to Mrs Michelle Susanne Frei under michelle.frei@ org.chem.ethz.ch. Applications sent to this adress will not be considered.

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.