Principal / Senior Principal Scientist - CMC Analytical Chemistry

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche .

In Roche´s Pharmaceutical Research and Early Development organisation (pRED) , we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicine. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

This role is situated within the preclinical Chemistry, Manufacturing, and Controls (pCMC) department, part of the Small Molecule Research organization in pRED Therapeutic Modalities (TMo). We pave the path for drug candidates from early research to development in a diverse and innovative environment. Collaborating actively with our discovery and development partners, we leverage cutting-edge technologies and scientific excellence to transform molecules into future medicines. As CMC experts, we bring a rich diversity of technical expertise in chemistry, formulation design, material science, and analytical chemistry, pioneering advancements in small molecules, peptides, and nucleic acid-based medicines.

The Opportunity

We are offering a unique opportunity for a Principal / Senior Principal Scientist in our Analytical Molecular Characterization group. As a Centre of Excellence for Analytics, we provide innovative methods and services for determining chemical structures, purities, and impurities, supporting portfolio projects throughout the entire value chain.

This role encompasses two primary areas of impact:

Scientific and Technical Expertise: You develop and run high-resolution Mass Spectrometry (MS) methods for the analysis of synthetic oligonucleotides

Leadership: You serve as the Analytical Molecular Characterization Leader, providing matrix leadership and scientific expertise to a diverse team of analytical specialists.

Role Impact:

• Innovative Analytics: You support the synthesis, development and production with cutting-edge analytics.

• Method Development: You develop and implement new methods to characterize innovative oligonucleotides.

• Stability and Synthesis Input: You contribute to stability studies and synthesis processes.

• Scientific Excellence: You improve scientific excellence by identifying relevant industry trends and maintaining academic partnerships, integrating these insights into the long-term scientific strategy for the group.

• GMP Guidance: You support release of GMP starting materials/GMP IPC analytics and method development

• Leadership: You provide matrix leadership and scientific expertise to a diverse team of analytical specialists.

• Strategic Vision: You define and implement mid- and long-term strategies and visions for the Analytical Molecular Characterization circle with the Leadership Team, translating them into actionable team goals.

• Collaboration and Relationship Building: You foster trustful relationships and effective collaboration with internal discovery and technical development teams as well as external partners.

Who You Are

• You possess an educational background that includes either a Master's degree with a minimum of 10 years of experience or a PhD in analytical chemistry or related fields, coupled with at least 5 years of professional experience in the industry.

• You have comprehensive technical expertise in chromatographic and spectroscopic analytics and their various applications.

• You demonstrate experience in mass spectrometry (MS) and synthetic oligonucleotide analytics, along with an advanced understanding of oligonucleotide synthesis and GMP/regulatory guidelines. Experience in synthetic peptide analytics is considered a valuable asset.

• You have spent at least 3 years leading a technical team. You demonstrate strong leadership skills, with a consistent track record of guiding multidisciplinary teams, effectively navigating ambiguity, and delivering impactful results through collaboration, all while possessing outstanding communication skills.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more .

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.