PhD or MD/PhD Candidate
Publication date:
08 April 2025Workload:
100%- Place of work:Bern
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Job summary
Join the University of Bern as a PhD or MD/PhD candidate! This role offers a collaborative research environment and excellent benefits.
Tasks
- Conduct research on MET receptor signaling and DNA damage response.
- Utilize mouse models and advanced proteomic techniques.
- Collaborate with interdisciplinary teams in neurodevelopment studies.
Skills
- Master's degree in relevant fields like molecular biology or biochemistry.
- Experience in experimental animal work and molecular biology techniques.
- Proficiency in bioinformatics and flow/mass cytometry.
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PhD or MD/PhD Candidate
Published 7 April 2025 Workplace Bern, Bern region, Switzerland CategoryHealth
PhD or MD/PhD candidate
100 %
Department for BioMedical Research (DBMR) , University of Bern
Start of employment: 1.6.20025 or by agreement
Temporary employment
The research of the Medová group at the Department for BioMedical Research (DBMR), University of Bern, Inselspital focuses on aspects related to signaling crosstalk between the MET receptor and cellular DNA damage responsse machinery. We invite applications for PhD. student position available within a research project "Adaptive Mechanisms of Receptor Tyrosine Kinases in Brain Development". This research is a collaboration with the Clinical Neuroscience Bern (Prof. Dr. A. Adamantidis) and the groups of Prof. Pat Levitt and Dr. Kathie Eagleson (Childrens’ Hospital of Los Angeles).
TasksRecently, we characterized a previously unreported phosphorylation on the oncogenic MET receptor (PMID:37188738). MET activation is also essential in neurodevelopment, yet there are significant knowledge gaps in understanding the relationship between the receptor phosphorylations and the intracellular pathways orchestrating diverse neurodevelopmental processes and, ultimately, brain functions.
In this collaborative project, we employ a multidisciplinary strategy that combines expertise in MET signaling and fundamental neurodevelopmental processes to determine how posttranslational modification of the MET receptor regulates its activity and cellular and functional phenotypes. The successful candidate will use the previously generated mouse models, proteomic techniques ((phospho-)proteomic, mass cytometry), and cellular and molecular biology-based assays for these investigations.
Requirements
We are searching for highly motivated, independent, and committed candidates with previous experience in experimental animal work and updated methods of molecular and cellular biology. Proven experience with bioinformatics tools, flow/mass cytometry, confocal microscopy as well as genome-editing approaches will serve as an advantage. Applicants should hold a Swiss or an equivalent Diploma/MSc degree in medicine, molecular biology, biochemistry, biomedical sciences, or pharmacology. Applicants must have the academic credentials for registration to the Graduate School of the University of Bern.
We offer
We offer an attractive and friendly international working environment and an opportunity to actively develop the collaborative project. All our students are enrolled in the Graduate School for BioMedical and Cellular Science (GCB) , University of Bern, which offers an excellent academic framework (seminars, workshops, journal clubs, networking opportunities, etc.). Employment conditions follow the standards of the University of Bern and the SNSF for PhD candidates.
Application and contact
Michaela Medova, michaela.medova@ unibe.ch
Your application should include a short letter of interest, curriculum vitae, a reference letter, university transcripts and certificates, your master thesis and (optional) relevant research papers. Send your application as a single PDF file no later than April 30, 2025 to michaela.medova@ unibe.ch .
