Technical R&D Scientist

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The Position

Technical R&D Formulation Scientist (Temporary Position - 3 years)

We advance science so that we all have more time with the people we love.

This position is part of the Synthetic Molecule Pharmaceutical Research and Development organization. Within Pharmaceutical Research and Development we transform molecules to medicines by designing and delivering customized clinical formulations and developing robust commercial drug products that benefit patients.

As a Scientist in Drug Product Development you will be responsible for developing robust formulations and lean manufacturing processes for oral dosage forms for new chemical entities. In this position you work with teams of scientists from other disciplines (chemistry, analytics, quality, regulatory and commercial production) and you represent the department in technical development teams.

The Opportunity

The main responsibilities of this challenging position include:

• Development and optimization of robust formulation and manufacturing process for oral solid drug products using various manufacturing technologies (i.e. batch and continuous technologies), including the scale-up and transfers to commercial manufacturing sites to facilitate the successful process validation at the sites.

• Development and implementation ofnew manufacturing technologies. In particular the review of available formulation science for continuous manufacturing to extract relevant generic learnings and consequences thereof, later to be applied on exemplar projects.

• Routine usage of statistical tools (e.g. DoEs) and risk assessment tools for QbD (e.g. FMEA).

• Participation in cross-site and cross-functional teams for the technical process development, the scale-up, the manufacturing of clinical supplies of NCE portfolio projects. In particular, application of materials science understanding to interface with particle engineering colleagues.

• Authorship and review oftechnical reports, manufacturing instructions, process validation documents, and parts of regulatory submissions to support licensing. Preparation of technical documentation (e.g. development reports) to support CMC regulatory submissions.

Who you are

• Undergraduate degree in pharmaceutical technology, food engineering, organic chemistry, analytical chemistry, chemical/ process engineering or material science with 0-3 years’ experience in oral solids drug product development or commercial manufacturing. Advanced degree (Masters/ PhD) is a plus.

• Experience in development of novel formulation concepts (e.g. pediatric formulation development, 3D printing), implementation of new technologies (e.g. Continuous Manufacturing) is a plus.

• Excellent communication skills, including some basic knowledge of German or willingness to learn German.

• Willingness to travel occasionally.

• Ability to drive for results and implement innovative solutions

• Highly motivated and able to work collaboratively as well as independently

• Openness and flexibility to change as well as “out of the box thinking” skills

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more .

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.