Associate / Scientist Solid Form Screening (temporary for 3 years)

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The Position

Global Technical Development (PTD) is an organization of over two thousand people globally that are integral for the mission of Roche to develop meaningful medicines for patients. Therefore, we actively collaborate and develop creative technical solutions to bridge early-stage, late-stage and commercial product needs. The mandate of the group is, to expertly deliver the pipeline and supply quality products to patients. The group excels in its work through innovation, teamwork, dedication, and mutual respect and contributes every single day, continuously improving what it does.

Synthetic Molecules Technical Development (PTDC) brings a broad range of experience across drug substance (DS), drug product (DP), and analytical sciences, and collaborates closely with key partners in the departments Research and Early Development (pRED / gRED), Synthetic Molecules (PTD). PTDC is responsible for late stage technical development of our synthetic molecules (SM) pipeline and the manufacture of DS and DP for clinical studies across our SM manufacturing network.

The Opportunity

We are seeking a Scientist / Associate to join the Solid Form Screening Group within the Solid State Sciences department of PTDC. As a center of excellence for solid forms and polymorphism, our group plays a crucial role in understanding the solid-form landscape for all small molecule development compounds. This enables the selection of the optimal solid form for drug development and its holistic control strategy.

Responsibilities:

• Perform salt, co-crystal, and polymorph screenings for small molecule drug substances in the laboratory.

• Independently manage projects from planning to execution, including result compilation and defense in project teams, as well as writing of source documents for regulatory submissions.

• Utilize a diverse range of methodologies and technologies, from manual experiments to automated high-throughput methods, to discover new crystal forms.

• Characterize solid forms and interpret analytical data in close cooperation with analytical partner laboratories (thermal analysis, X-ray diffraction, spectroscopy, ssNMR) and ensure data integrity in the documentation.

• Innovate and improve the applied methodologies, technologies, and digital workflows.

• Manage the lifecycle (including maintenance and calibration) of assigned equipment.

• Collaborate with an interdisciplinary team to optimize administrative procedures and laboratory organization, focusing on SHE (Safety, Health, and Environment), sustainability, and data integrity.

Who You Are:

You demonstrate dedication and extensive experience in solid-state sciences and are motivated to grow and innovate through collaboration. You bring these skills to this role:

• Advanced education (Master’s or Ph.D.) in the fields of Solid State Sciences or Chemistry, Physics, or Pharmacy preferred, or significant lab technician experience in Solid State Sciences

• Expertise in solid-form screening and solid-state analytics

• Excellent laboratory skills and observational powers

• Skill in computer-controlled lab automation and digital workflows

• Passion for solving complex problems and learning new techniques

• Team-oriented with excellent communication skills

• Natural inclination to coach and mentor less experienced colleagues

• Open to adopting new working methods, supporting team flexibility

• Proficient in English and German

• Additional skills that count as a plus: solid-state modeling, in-depth crystallographic knowledge, and crystallization process development

We look forward to welcoming a motivated and innovative colleague to our Solid Form Screening Group. If you are excited about making impactful contributions to Solid State Sciences at Roche, we encourage you to apply.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more .

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.