Scientist (In-Vivo) Oncology
Publication date:
09 October 2024Workload:
100%Contract type:
Unlimited employment- Place of work:TANGIER
Johnson & Johnson is currently seeking a Scientist (In Vivo) Oncology located in Spring House, PA. At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.
For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Rooted in Our Credo, the values of DEI fuel our pursuit to create a healthier, more equitable world. Our diverse workforce and culture of belonging accelerate innovation to solve the world’s most pressing healthcare challenges. We know that the success of our business – and our ability to deliver meaningful solutions – depends on how well we understand and meet the diverse needs of the communities we serve. Which is why we foster a culture of inclusion and belonging where all perspectives, abilities and experiences are valued and our people can reach their potential. At Johnson & Johnson, we all belong.
The Scientist will join the Oncology in vivo group efforts in the characterization and development of small molecules and biologics including those that function as immune modulators for the treatment of cancer. They may also characterize new cell therapies such as CAR-Ts. They will be responsible for contributing to the ex vivo and in vivo studies for multiple research programs across the different stages of pre-clinical drug discovery. Their responsibilities include the design, execution and interpretation of in vivo studies for the validation and characterization of targets or therapeutic agents in the area of oncology and tumor immunology. Specifically, the candidate will establish and perform in vivo model development, target inhibition, efficacy, mechanism of action, and pharmacokinetic/pharmacodynamics (PK/PD) biomarker studies, and will evaluate the influence of dose, schedule and therapeutic combinations in various cancer models.
Key Responsibilities:
- Independently design, perform, interpret and report standard in vivo preclinical cancer models
- Conduct methods of in vivo experimentation, including tumor implantation, dosing, proper handling of chemotherapeutics, tumor measurement, health monitoring, and data collection and analyses
- May establish and perform in vivo model development, including the improvement, adaptation, or change to existing research methods
- May contribute to ex vivo analysis of tumor cells or immune cells for flow cytometry, IHC, or MSD
- May perform bioluminescent imaging studies using molecular reporters or disseminated/ metastatic disease models
- Analyze using appropriate statistical methods and present data in a clear presentation-ready format
-- Manage multiple in vivo experiments or projects simultaneously
- Will contribute on various projects outside of their own, collaborate with partners from all relevant functions, and keep up-to-date in the literature related to their field
- Act as a resource on project teams with clear and professional verbal and written communication.
- Some weekend, evening, and holiday dosing/ animal monitoring required
Contact
Synthes GmbH