Quantitative Systems Pharmacology Modeler
Veröffentlicht:
23 April 2024Pensum:
100%Vertrag:
Festanstellung- Arbeitsort:Basel
Modelling of Iron Metabolism
Project:
Iron is essential for life on Earth and critical for human health. It enables oxygen transport via haemoglobin, supports cellular energy production, and plays a role in enzyme function and detoxification. A lack of iron causes anaemia, leading to fatigue and weakness, while excess iron can result in organ damage.
Mechanistic mathematical modelling of iron metabolism could offer valuable insights for drug development, particularly in hematology. However, existing iron metabolism models found in the literature often lack technical comprehensibility and do not integrate most recent knowledge from mechanistic studies and publicly available datasets. The internship candidate will revisit existing iron metabolism models and integrate them with novel scientific insights using state-of-the-art modelling approaches.
Internship goals:
- Gaps or areas needing refinement based on current biological understanding and/ or technical considerations are identified.
- A comprehensive structural model of iron metabolism (using ODEs) is developed.
- Validated physiological parameters using Nonlinear Mixed Effects Modelling (with Monolix software) and in-house datasets compiled from literature are estimated.
- Various physiological and pathological conditions, offering new perspectives for drug development in diseases like anaemia and cancer, are simulated.
Requirements:
- Bachelor’s or Master’s degree from ETHZ, EPFL or any other recognized university.
- Rigorous, excellent analytical skills
- Confident in understanding, using and numerically solving ordinary differential equations (ODEs)
- Expert in scientific programming using R (or some other closely related scripting language)
- Pro-active and independent work style
- Proficient scientific communication skills
- Proficient in oral and written English
- Strong team player, good communication skills and ability to work with cross-cultural and diverse project teams and clients
Languages: English (advanced).
Location: Basel.
Company: LYO-X is a Swiss company located in Basel providing global consulting and Systems Pharmacology modelling services dedicated to the preclinical and clinical development of biologics and cell-based therapies.
Contact: If you are interested and would like to contribute to the growth of LYO-X, we would be pleased to receive your application including a letter of application, curriculum vitae, Bachelors and Masters grades, reference letters and job references. Please send your application to E-Mail schreiben.